Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2

<div>Effects of diquat alone or combined with GSPB2 on antioxidant enzyme activity and MDA content in ovarian tissue. Mice were treated with diquat or saline or in combination with GSPB2. Ovaries were then collected and homogenized for the assay of antioxidant activity. (a) T-SOD activity in ovarian tissue. (b) GSH-PX activity in ovarian tissue. (c) CAT activity in ovarian tissue. (d) MDA content in ovarian tissue. 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id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> versus diquat alone.</div>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stress and Protective Effects of Grape Seed Procyanidin B2 