Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease

Figure 2

The hepatoprotection afforded by schisandrin B (Sch B) in relation to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The possible undesirable effect of Sch B is indicated in the blue box while the potential beneficial effects of Sch B are indicated in the green box. ATGL: adipose triglyceride lipase; HSL: hormone-sensitive lipase; HMG-CoAR: 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase; TNF-α: tumor necrosis factor-α; SREBP1: sterol regulatory element-binding protein-1; ACC: acetyl-CoA carboxylase; FAS: fatty acid synthase; Nrf2: nuclear factor (erythroid-derived 2)-like 2; ROS: reactive oxygen species; IL-6: interleukin-6; Grp78: glucose-regulated protein-78; CHOP: CCAAT/enhancer binding protein homologous protein; XBP1: X-box-binding protein-1; CCl₄: carbon tetrachloride.