Activation of ALDH2 with Low Concentration of Ethanol Attenuates Myocardial Ischemia/Reperfusion Injury in Diabetes Rat Model

Table 1

Hemodynamic parameters in the isolated perfused rat hearts subjected to ischemia and reperfusion (I/R) (mean SD, ).

Variable	Baseline	Ischemia	Reperfusion
		30 min	5 min	10 min	120 min
LVDP (% of baseline )
C I/R	100 0	59 13	63 13	65 14	58 4
DM I/R	100 0	33 7	42 12	48 5	32 5
DM + EtOH I/R	100 0	59 15	93 12	90 7	58 13
DM + EtOH + CYA I/R	100 0	36 7	44 8	44 8	35 9
DM + EtOH + Atr I/R	100 0	38 8	48 8	47 8	30 4
DM + EtOH + Wor I/R	100 0	39 6	47 8	44 7	32 3
LVEDP (% of baseline)
C I/R	100 0	101 1	116 2	120 10	177 11
DM I/R	100 0	151 15	177 14	159 9	262 27
DM + EtOH I/R	100 0	104 7	143 6	141 8	182 14
DM + EtOH + CYA I/R	100 0	155 11	182 11	160 12	254 20
DM + EtOH + Atr I/R	100 0	147 20	166 3	166 5	251 16
DM + EtOH + Wor I/R	100 0	168 19	176 7	170 11	281 45
(% of baseline)
C I/R	100 0	64 10	80 15	78 12	55 8
DM I/R	100 0	48 8	43 9	46 5	34 6
DM + EtOH I/R	100 0	60 14	91 17	91 19	62 11
DM + EtOH + CYA I/R	100 0	47 7	46 6	47 6	32 7
DM + EtOH + Atr I/R	100 0	48 6	45 2	47 4	34 7
DM + EtOH + Wor I/R	100 0	49 9	43 6	44 4	33 5
(% of baseline)
C I/R	100 0	59 13	59 10	59 1	41 5
DM I/R	100 0	42 9	42 6	46 9	31 4
DM + EtOH I/R	100 0	62 5	85 10	84 12	48 6
DM + EtOH + CYA I/R	100 0	45 4	46 7	44 4	35 4
DM + EtOH + Atr I/R	100 0	43 5	49 5	45 4	33 4
DM + EtOH + Wor I/R	100 0	46 4	44 5	43 4	30 5
RPP (% of baseline)
C I/R	100 0	59 6	62 17	62 8	33 3
DM I/R	100 0	26 7	32 8	28 7	18 4
DM + EtOH I/R	100 0	55 13	76 7	79 19	37 6
DM + EtOH + CYA I/R	100 0	29 5	28 5	25 6	15 5
DM + EtOH + Atr I/R	100 0	28 4	34 6	31 6	16 4
DM + EtOH + Wor I/R	100 0	32 8	30 3	25 4	18 2

, versus C I/R; versus DM I/R; , versus DM + EtOH I/R.