The Plant-Derived Chalcone 2,2′,5′-Trihydroxychalcone Provides Neuroprotection against Toll-Like Receptor 4 Triggered Inflammation in Microglia

Figure 3

225THC modulates inflammatory cytokine and chemokine responses in murine BV2 microglial cells. 225THC-modulation of cytokine/chemokine secretion by the BV2 microglial cell line. ELISA assessment of cytokine ((a) TNF-α) and chemokine ((b) MCP-1; (c) RANTES; (d) MIP) secretion by BV2 microglial cells following stimulation with LPS (2 μg/mL) for 24 h in the presence of 225THC at the concentrations indicated. Statistical analysis was performed by a two-way ANOVA with Bonferroni post hoc analysis; indicates , ; ns, not significant when compared with basal or as indicated.

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