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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 6354261, 9 pages
http://dx.doi.org/10.1155/2016/6354261
Research Article

Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts

1Center for Metabolic Function Regulation, Wonkwang University School of Medicine, Iksan 570-749, Republic of Korea
2Division of Hematology/Oncology, Gachon University Gil Medical Center, Incheon 405-760, Republic of Korea
3Department of Microbiology & Immunology, Institute of Medical Science, Chonbuk National University Medical School, Jeonju 560-182, Republic of Korea
4Department of Biochemistry, Institute of Medical Science, Chonbuk National University Medical School, Jeonju 560-182, Republic of Korea
5Department of Pediatrics, Institute of Clinical Science, Chonbuk National University Medical School, Jeonju 560-182, Republic of Korea
6Department of Korean Physiology, Wonkwang University School of Korean Medicine, Iksan 570-749, Republic of Korea
7Department of Oral Biochemistry and Institute of Biomaterials, Implant, School of Dentistry, Wonkwang University, Iksan 570-749, Republic of Korea

Received 25 March 2016; Revised 4 July 2016; Accepted 26 July 2016

Academic Editor: Juan F. Santibanez

Copyright © 2016 Eun-Mi Noh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [7 citations]

The following is the list of published articles that have cited the current article.

  • Su-Ying Wen, Jia-Yi Chen, Yueh-Shan Weng, Ritu Aneja, Chih-Jung Chen, Chih-Yang Huang, and Wei-Wen Kuo, “ Galangin suppresses H 2 O 2 -induced aging in human dermal fibroblasts ,” Environmental Toxicology, 2017. View at Publisher · View at Google Scholar
  • Eun-Mi Noh, Jeong-Mi Kim, On-Yu Hong, Hyun-Kyung Song, Jong-Suk Kim, Kang-Beom Kwon, and Young-Rae Lee, “PTEN inhibits replicative senescence-induced MMP-1 expression by regulating NOX4-mediated ROS in human dermal fibroblasts,” Journal of Cellular and Molecular Medicine, 2017. View at Publisher · View at Google Scholar
  • Pan Kang, Weigang Zhang, Xuguang Chen, Xiuli Yi, Pu Song, Yuqian Chang, Shaolong Zhang, Tianwen Gao, Chunying Li, and Shuli Li, “TRPM2 mediates mitochondria-dependent apoptosis of melanocytes under oxidative stress,” Free Radical Biology and Medicine, 2018. View at Publisher · View at Google Scholar
  • Mengqian Li, Liting You, Jianxin Xue, and You Lu, “Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini Review,” Frontiers in Pharmacology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Diethard Tautz, Cemalettin Bekpen, Chen Xie, and Almut Nebel, “Involvement of SPATA31 copy number variable genes in human lifespan,” Aging, vol. 10, no. 4, pp. 674–688, 2018. View at Publisher · View at Google Scholar
  • Yaqiong Tian, Hui Li, Ting Qiu, Jinghong Dai, Yingwei Zhang, Jingyu Chen, and Hourong Cai, “Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF‐κB activation,” Aging Cell, pp. e12858, 2018. View at Publisher · View at Google Scholar
  • Jun Li, Xuemei Yang, Fang Liu, Yaman Song, and Yuanke Liu, “Evaluation of differentially expressed microRNAs in vitrified oocytes by next generation sequencing,” The International Journal of Biochemistry & Cell Biology, 2019. View at Publisher · View at Google Scholar