Review Article
DNA Tumor Viruses and Cell Metabolism
Table 1
Human tumor DNA viruses.
| Family | Virus | Virus-cell interaction | Associated disease | Level of association % | Size of genome kb |
| Herpesviruses | Epstein-Barr virus, EBV | Episomal, rarely integrated in transformed cells | Endemic Burkitt’s lymphoma (BL) AIDS-asscoiated lymphoma Nasopharengyal carcinoma (NPC) | 98 100 100 | 172 | Kaposi sarcoma herpes virus, KSHV | Episomal, rarely integrated in transformed cells | Kaposi’s sarcoma | 97 | 165 |
| Polyoma viruses | John Cunningham Virus, JCV | Episomal, rarely integrated in transformed nonpermissive cells | Progressive multifocal leukoencephalopathy | 50–80 | 5.2 | Virus of B.K. patient, BKV | Episomal, rarely integrated in transformed nonpermissive cells | Nephropathy Nephritis Hemorrhagic cystitis | 10–20 | 5.2 | SV40 | Episomal, rarely integrated in transformed nonpermissive cells | Mesothelioma | 10–20 cofactor | 5.2 |
| Papilloma viruses | HPV | Episomal, integrated in transformed cells | Cervical cancer | 71–88 (types 16 and 18) | 8 |
| Adenoviruses | | Integrated in transformed nonpermissive cells | Small cell lung cancer Childhood ALL | No data | 35 kb (type 11) |
|
|