DNA Tumor Viruses and Cell Metabolism

Table 1

Human tumor DNA viruses.

Family	Virus	Virus-cell; interaction	Associated disease	Level of association; %	Size of genome; kb
Herpesviruses	Epstein-Barr virus, EBV	Episomal, rarely integrated in transformed cells	Endemic Burkitt’s lymphoma (BL); AIDS-asscoiated lymphoma; Nasopharengyal carcinoma (NPC)	98; 100; 100	172
	Kaposi sarcoma herpes virus, KSHV	Episomal, rarely integrated in transformed cells	Kaposi’s sarcoma	97	165
Polyoma viruses	John Cunningham; Virus, JCV	Episomal, rarely integrated in transformed nonpermissive cells	Progressive multifocal leukoencephalopathy	50–80	5.2
	Virus of B.K. patient, BKV	Episomal, rarely integrated in transformed nonpermissive cells	Nephropathy; Nephritis; Hemorrhagic cystitis	10–20	5.2
	SV40	Episomal, rarely integrated in transformed nonpermissive cells	Mesothelioma	10–20; cofactor	5.2
Papilloma viruses	HPV	Episomal, integrated; in transformed cells	Cervical cancer	71–88; (types 16 and 18)	8
Adenoviruses		Integrated in transformed nonpermissive cells	Small cell lung; cancer Childhood ALL	No data	35 kb (type 11)