Table 1: Human tumor DNA viruses.

FamilyVirusVirus-cell
interaction
Associated diseaseLevel of association
%
Size of genome
kb

HerpesvirusesEpstein-Barr virus, EBVEpisomal, rarely integrated in transformed cellsEndemic Burkitt’s lymphoma (BL)
AIDS-asscoiated lymphoma
Nasopharengyal carcinoma (NPC)
98
100
100
172
Kaposi sarcoma herpes virus, KSHVEpisomal, rarely integrated in transformed cellsKaposi’s sarcoma97165

Polyoma virusesJohn Cunningham
Virus, JCV
Episomal, rarely integrated in transformed nonpermissive cellsProgressive multifocal leukoencephalopathy50–805.2
Virus of B.K. patient, BKVEpisomal, rarely integrated in transformed nonpermissive cellsNephropathy
Nephritis
Hemorrhagic cystitis
10–205.2
SV40Episomal, rarely integrated in transformed nonpermissive cellsMesothelioma10–20
cofactor
5.2

Papilloma virusesHPVEpisomal, integrated
in transformed cells
Cervical cancer71–88
(types 16 and 18)
8

AdenovirusesIntegrated in transformed nonpermissive cellsSmall cell lung
cancer Childhood ALL
No data35 kb (type 11)