Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies

Figure 2

Targets of polyphenol anticancer therapies. Epigenetic pathways, cellular redox status, and cancer stem cells as therapeutic targets of polyphenol anticancer therapies as extensively discussed in the text. Depending on acute or chronic treatment a prooxidant activity may induce, respectively, high ROS-mediated cytotoxicity or low ROS-mediated cytostasis. According to the figure, several natural compounds as resveratrol, artichoke polyphenols, ginsenoside Rg-3, and quercetin induce a prooxidant apoptotic mechanism at high concentrations whereas low doses and chronic exposure trigger a ROS-epigenetic mediated cellular senescence.