CD36/Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice

Figure 4

Markers of redox status, antioxidant enzymes, and sirtuin 1 protein expression in liver. (a) Malondialdehyde (MDA) in liver of WT and ACE2 mice at the age of 3 and 6 months (nM⋅mg protein⁻¹); (b) superoxide dismutase (SOD) activity in the liver (UI⋅Protein mg⋅mL⁻¹); (c) catalase activity in the liver (nmol/min/mL⋅Protein mg⋅mL⁻¹) of WT and ACE2 mice at the age of 6 months; (d) relative mRNA and (e) protein expression of uncoupling protein 2 (UCP2) in the liver (arbitrary units); (f) sirtuin 1 protein expression in the liver (arbitrary units) of WT and ACE2 mice at the age of 3 and 6 months. Each bar graph represents the mean ± SEM. Student’s t test: ; .

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