The H2S Donor NaHS Changes the Expression Pattern of H2S-Producing Enzymes after Myocardial Infarction
Exogenous H2S increased plasma H2S levels and the three H2S-producing enzymes expression in ischaemic myocardium. (a) The expressions of CSE and 3-MST significantly decreased, whereas CBS expression increased 2 weeks after MI surgery. (b) In noninfarcted myocardium, NaHS treatment for 2 weeks increased the expression of CSE (50 μmol/kg/day) and 3-MST (25 μmol/kg/day), while NaHS (25–100 μmol/kg/day) did not change expression of CBS; (c) H2S donor NaHS (25–100 μmol/kg/day) increased the expression of the three enzymes in ischaemic myocardium 2 weeks after MI. (d) Changes in plasma H2S levels in sham, MI surgery control, and NaHS treatment groups. Plasma H2S levels decreased 2 weeks after MI, whereas 50 and 100 μmol/kg/day NaHS treatment ameliorated this trend. Numbers inside bars denote the number of animals per group. Values are mean ± SE. .