Antioxidant and Vasodilator Activity of Ugni molinae Turcz. (Murtilla) and Its Modulatory Mechanism in Hypotensive Response

Figure 3

Possible antioxidant response of flavonoids compounds combined with Nrf2 pathway. Extracellular reduction of oxidative stress scavenging by flavonoids compound reducing an oxidative damage by H₂O₂, decreasing the concentration potentially dangerous to membrane and intracellular milieu. The reduction of intracellular oxidative stress can be mediated by Keap1/Nrf2 pathway by the activation of antioxidant response element (ARE) through the Nrf2 phosphorylated and translocated to nucleus; this activates the transcription factor to increase concentration of antioxidant complex, reducing ROS by enzymatic system. In this sense, the flavonoids can act as scavenger of ROS, enhancing the intracellular ROS balance and reducing the lipid peroxidation and the propagative effect.