Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity

Figure 5

Effects of resveratrol pretreatment on ROS and ATP concentrations in PC12 cells exposed to rotenone. (a) ROS formation is induced in PC12 cells exposed to rotenone with high fluorescence intensity compared to the control group. Resveratrol pretreatment could significantly suppress ROS formation induced by rotenone. (b) Rotenone exposure leads to a significant reduction in the ATP concentration in PC12 cells. There was an increase in ATP concentration in PC12 cells with resveratrol pretreatment compared to the control group. The results are presented as the mean ± S.E.M. versus control group; versus R group.

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