Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer
LXA4 attenuated cell invasion via inhibiting ROS pathway. (a) Cell invasion tested by transwell chamber in Panc-1 cells treated with vehicle (methanol), LXA4 (400 nM), or ROS scavenger NAC (20 mM). (b) The quantified results of (a). (c) Intracellular ROS determined in cells treated in (a). Cells incubated with DCF-DA for 20 min were washed with PBS three times and then lysed by RIPA lysis buffer and tested by fluorimetry at 510 nm. It was normalized by total protein. versus vehicle control.
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