(−)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats

Figure 5

Effect of (−)-epicatechin treatment on nitric oxide synthase activity (a), correlation between total distance traveled in the open-field and nitric oxide synthase activity (b) and gene expression of nNOS (c), iNOS (d), eNOS (e), and the p22phox (f) in the brainstem of spontaneously hypertensive rats. Values represent mean ± SEM; for Cont and –10 for Epi. versus Cont group. Abbreviations: Cont: control group, Epi: (−)-epicatechin-treated group, NOS: nitric oxide synthase, eNOS: endothelial NOS, iNOS: inducible NOS, nNOS: neuronal NOS, and p22phox: subunit of nicotinamide adenine dinucleotide phosphate oxidase.

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