(−)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats

Figure 6

Effect of (−)-epicatechin treatment on nitric oxide synthase (NOS) activity (a), correlation between total distance traveled in the open-field and NOS activity (b) and gene expression of nNOS (c), iNOS (d), eNOS (e), and p22phox (f) in the cerebellum of spontaneously hypertensive rats. Values represent mean ± SEM; for Cont and –10 for Epi. versus Cont group. Abbreviations: Cont: control group, Epi: (−)-epicatechin-treated group, eNOS: endothelial NOS, iNOS: inducible NOS, nNOS: neuronal NOS, and p22phox: subunit of nicotinamide adenine dinucleotide phosphate oxidase.

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