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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 6974257, 9 pages
Research Article

Oxidation-Reduction Potential as a Biomarker for Severity and Acute Outcome in Traumatic Brain Injury

1Department of Trauma Research, Swedish Medical Center, Englewood, CO 80113, USA
2InterMountain Neurosurgery, St. Anthony Hospital, Lakewood, CO 80228, USA
3Medical Center of Plano, Plano, TX 75075, USA
4Department of Trauma Research, St. Anthony Hospital, Lakewood, CO 80228, USA
5Department of Biomedical Sciences, Rocky Vista University, Aurora, CO 80134, USA
6Penrose-St. Francis Health Services, Colorado Springs, CO 80907, USA

Received 4 May 2016; Revised 12 July 2016; Accepted 17 July 2016

Academic Editor: Rodrigo Franco

Copyright © 2016 Kimberly B. Bjugstad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


There are few reliable markers for assessing traumatic brain injury (TBI). Elevated levels of oxidative stress have been observed in TBI patients. We hypothesized that oxidation-reduction potential (ORP) could be a potent biomarker in TBI. Two types of ORP were measured in patient plasma samples: the static state of oxidative stress (sORP) and capacity for induced oxidative stress (icORP). Differences in ORP values as a function of time after injury, severity, and hospital discharge were compared using ANOVAs with significance at . Logit regression analyses were used to predict acute outcome comparing ORP, Injury Severity Score (ISS), Abbreviated Injury Scale (AIS), and Glasgow Coma Scale (GCS). Antioxidant capacity (icORP) on day 4 was prognostic for acute outcomes (). An odds ratio of 4.08 was associated with poor acute outcome when icORP > 7.25 μC. IcORP was a better predictor than ISS, AIS, or GCS scores. sORP increased in those with the highest ISS values (). Based on these findings ORP is useful biomarker for severity and acute outcome in TBI patients. Changes in ORP values on day 4 after injury were the most prognostic, suggesting that patients’ response to brain injury over time is a factor that determines outcome.