Oxidation-Reduction Potential as a Biomarker for Severity and Acute Outcome in Traumatic Brain Injury

Figure 3

ORP measures increase as a function of ISS groups on the fourth day after injury. (a/d) Admission measures of sORP (a) or icORP (d) did not change as a function of ISS severity. Regardless of severity, groups had similar sORP and icORP values. (b/e) On day 4, sORP measures were significantly higher in the moderate, severe, and profound groups compared to the mild group (b). The severe and profound groups both had increased icORP measures (lowered antioxidant capacity) on day 4 compared to the moderate or mild groups (e). Thus, with increasing level of severity, there were significant increases in sORP and icORP. (c/f) No significant differences were found in ORP measures between moderate, severe, and profound severity groups on day 7 after injury. The mild group did not have enough subjects to be included in this analysis. Data are presented as means standard error of the mean (sem); means significantly greater than the mild severity group; .

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