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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 7031397, 17 pages
Research Article

The Natural Polyphenol Epigallocatechin Gallate Protects Intervertebral Disc Cells from Oxidative Stress

1Department of Health Sciences and Technology, Institute for Biomechanics, ETH Zurich, Hoenggerbergring 64, 8093 Zurich, Switzerland
2Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan
3Prodorso, Walchestrasse 15, 8006 Zurich, Switzerland
4Department of Rheumatology, University Hospital, Zurich, Switzerland

Received 20 November 2015; Revised 30 January 2016; Accepted 16 February 2016

Academic Editor: Nageswara Madamanchi

Copyright © 2016 Olga Krupkova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary figure 1. H2O2 sensitivity study, p21 expression during cell culture period, the effect of H2O2 on senescence-associated secretory phenotype and confirmation of the LY294002 activity/specificity.

Supplementary figure 2. The expression of p16 Ink4a in oxidative stress-induced senescence of IVD cells.

Supplementary figure 3. The role of reactive oxygen species and mitochondria in senescence and apoptosis of IVD cells (schematic).

  1. Supplementary Material