SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model

Figure 1

Expression and activity of SIRT1 protein in renal tissue after cecal ligation and puncture (CLP). (a) Representative western blot of SIRT1 proteins (upper panel) and densitometric analyses (lower panel); (b) SIRT1 activity was determined using a SIRT1 Assay kit and normalized to that of the control group. The time points were set at 4, 8, 16, and 24 h after CLP treatment. Values shown are the mean ± SEM. versus the control group; and versus the 4 h group; versus the 8 h group; versus the 16 h group. . SIRT1, sirtuin; GAPDH, glyceraldehyde 3-phosphate dehydrogenase.

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