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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 7367641, 8 pages
Research Article

Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients

1Department of Biology, National Autonomous University of Mexico (UNAM), 04510 Mexico City DF, Mexico
2Economy Department, Autonomous Metropolitan University-Iztapalapa, 09340 Mexico City, DF, Mexico
3Research Department, Regional Hospital “Lic. Adolfo López Mateos”, ISSSTE, 01030 Mexico City, DF, Mexico
4Molecular Biology Department, National Institute of Cardiology “Ignacio Chávez”, 14080 Mexico City, DF, Mexico
5Department of Immunology, National Institute of Respiratory Diseases “Ismael Cosío Villegas”, 14080 Mexico City, DF, Mexico
6Molecular Genetics Laboratory, National School of Anthropology and History, 14030 Mexico City, DF, Mexico

Received 4 January 2016; Revised 29 March 2016; Accepted 5 April 2016

Academic Editor: Silvana Hrelia

Copyright © 2016 Angélica Saraí Jiménez-Osorio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The nuclear factor-erythroid 2- (NF-E2-) related factor 2 (Nrf2) is abated and its ability to reduce oxidative stress is impaired in type 2 diabetes and obesity. Thus, the aim of this study was to explore if polymorphisms in Nrf2 and target genes are associated with diabetes and obesity in Mexican mestizo subjects. The rs1800566 of NAD(P)H:quinone oxidoreductase 1 (NQO1) gene, rs7211 of thioredoxin interacting protein (TXNIP) gene, rs2071749 of heme oxygenase-1 (HMOX1) gene, and the rs6721961 and the rs2364723 from Nrf2 gene were genotyped in 627 diabetic subjects and 1020 controls. The results showed that the rs7211 polymorphism is a protective factor against obesity in nondiabetic subjects (CC + CT versus TT, OR = 0.40, ) and in women (CC versus CT + TT, OR = 0.7, ). TT carriers had lower high-density lipoprotein cholesterol levels and lower body mass index. The rs2071749 was positively associated with obesity (AA versus AG + GG, OR = 1.25, ). Finally, the rs6721961 was negatively associated with diabetes in men (CC versus CA + AA, OR = 0.62, ). AA carriers showed lower glucose concentrations. No association was found for rs1800566 and rs2364723 polymorphisms. In conclusion, the presence of Nrf2 and related genes polymorphisms are associated with diabetes and obesity in Mexican patients.