CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway
CD38-deficient hearts are resistant to ischemia/reperfusion (I/R) injury in vitro. (a) The images of left ventricular (LV) slices. The mice were subjected to 30 minutes of LAD ischemia followed by 24 h of reperfusion and the infarct area was determined by Evans blue and TTC staining. The nonischemic area is in blue, the area at risk (AAR) is in red, and the infarct area is in white. (First and second row: scale bars = 1000 μm, third row: scale bar = 600 μm.) (b) Quantitative analysis of infarct size/area of CD38 KO and WT hearts after I/R injury. Myocardial injury caused by I/R is significantly attenuated in CD38 KO mice and the WT mice treated with exogenous NAD (2 mg/10 g body weight, IP) compared with WT mice, seeing that the inhibitory percentages of the ratio of infarct size/AAR were reduced from % (WT) to % (WT + NAD) or % (CD38 KO). and and , .
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