Table 1: Anti-inflammatory activities of some polyphenolic compounds.

Phenolic compounds Anti-inflammatory activities Inflammatory markers Mechanism References

Apigenin Inhibiting LPS-induced inflammationCasp-1, IL-1βInhibiting NLRP3 inflammasome
Zhang et al.,
2014 [8]
Catechin Against monosodium urate-induced inflammation IL-1βModulating NLRP3 inflammasome
Jhang et al.,
2015 [9]
Epigallocatechin gallate Suppressing melanoma growth NLRP1, IL-1β, NFκB Inhibiting NLRP3 activation Ellis et al.,
2011 [10]
Epigallocatechin gallate Protecting endothelial cells against PCB 126 induced inflammation GST, NQO1, MCP-1,
Modulating AhR/Nrf2 pathway Han et al.,
2012 [11]
Ellagic acid Ameliorating monocrotaline-induced pulmonary artery hypertension IL-1β, IL-2, IL-4, IL-
6, IL-10, IFN-γ,
Suppressing NLRP3 inflammasome
Tang et al.,
2015 [12]
Green tea Decreasing PCB 126 induced oxidative stress SOD1, GSR, NQO1,
Stimulating AhR/Nrf2 pathway Newsome et
al., 2014 [13]
Homoplantaginin Inhibiting palmitic acid-induced inflammation IL-1β, ICAM-1,
MCP-1, Casp-1
Interacting with ROS sensitive thioredoxin protein He et al., 2016
Luteoloside Inhibiting proliferation, invasion, and metastasis of HCC cells ROS, NLPR3, Casp-
1, IL-1β
Suppressing NLRP3 inflammasome
Fan et al., 2014
Plant polyphenols Modulating the inflammatory response of human keratinocytes MCP-1, IL-10, IL-8,
TNF-α, IL-6
Impairing phosphorylation EGF induced NFκB via regulating AhR signaling Potapovich et al., 2011 [16]
Quercetin and
Repair of kidney injury IL-1β, IL-18 Suppressing NLRP3 inflammasomes Wang et al.,
2012 [17]
Resveratrol Ameliorating hepatic metaflammation IL-1, TNF-α, IL-6 Inhibiting NLRP3 activation Yang and Lim 
2014 [18]
Rutin Reducing inflammation in pancreas Casp-1, IL-1β, ASC- NLRP3, IL-18, TNF-αSuppressing NLRP3 inflammasome
Aruna et al.,
2014 [19]
TangeretinAttenuating oxidative stress and protecting hepatocellular architecture CYP1B1, CYP2E1,
g-GCS, NQO1, HO-1, IL-6, TNF-α, IL-1β
Stimulating AhR/Nrf2-Keap1 pathwayArivazhagan and Subramanian 2015 [20]

LPS: lipopolysaccharide; Casp-1: caspase-1; IL: interleukin; NLRP: NOD-like receptor protein; NF-κB: nuclear factor-kappa B; GST: glutathione S-transferase; NQO1 (NAD(P)H: quinone oxidoreductase l); MCP-1: monocyte chemotactic protein-1; ICAM-1: intercellular adhesion molecule-1; AhR: aryl hydrocarbon receptor; IFN-γ: interferon-gamma; MIP-1: macrophage inflammatory protein-1; MDA: malondialdehyde; PCB: polychlorinated biphenyls; SOD: superoxide dismutase; GSR: glutathione S-reductase; GST: glutathione S-transferase; HCC: hepatocellular carcinoma cells; ROS: oxygen reactive species; TNF-α: tumor necrosis factor-alpha; EGF: epidermal growth factor; ASC: apoptosis associated speck-like CARD containing protein; CYPs, cytochrome P450 dependent monooxygenases; g-GCS: glutamate-cysteine ligase; HO-1: heme oxygenase-1.