Sociodemographic and Lifestyle Determinants of Plasma Oxidative Stress Markers 8-OHdG and F2-Isoprostanes and Associations with Metabolic Syndrome

Table 3

Associations of metabolic factors and chronic disease with plasma 8-OHdG and F2-isoprostanes.

	8-OHdG		F2-isoprostanes
Waist circumference (cm)	−0.06	0.071	0.08	0.026
Triglycerides (mmol/L)	−0.04	0.231	0.21	<0.001
HDL-cholesterol (mmol/L)	−0.01	0.831	0.23	<0.001
LDL-cholesterol (mmol/L)	−0.05	0.176	0.19	<0.001
Fasting glucose (mmol/L)	−0.01	0.742	0.02	0.573
Systolic blood pressure (mm Hg)	−0.02	0.482	0.13	<0.001
Diastolic blood pressure (mm Hg)	−0.04	0.215	0.13	<0.001
Metabolic syndrome (Mets) (Yes (ref. No))	−0.05	0.143	0.08	0.013
of MetS components	−0.04	0.198	0.11	0.001
of chronic diseases	0.01	0.713	0.00	0.988

8-OHdG and F2-isoprostanes were logged transformed for analysis. All analyses were adjusted for research site. Results are reported as standardized regression coefficients. Analyses on 8-OHdG were adjusted for age, sex, cotinine, and fasting. Analyses on F2-isoprostanes were adjusted for age, sex, education, cotinine, alcohol use, supplement use, season of sample collection, and fasting.
Triglycerides, HDL-cholesterol, LDL-cholesterol, fasting glucose, systolic and diastolic blood pressure were all adjusted for use of lipid, cholesterol, and glucose or blood pressure lowering medication. HDL: high-density lipoprotein; LDL: low-density lipoprotein; : number; MetS: metabolic syndrome.