Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway

Figure 2

Effect of SFN administration on pancreatic levels of MDA, SOD, and GPx in mice with cerulein-induced AP. (a) Pancreatic MDA level (indicator of lipid peroxidation) after SFN treatment in mice with cerulein-induced AP was measured using the thiobarbituric acid (TBA) method. (b, c) Pancreatic levels of the SOD and GPx (antioxidant enzymes responsible for scavenging toxic metabolites generated by free radicals) after SFN treatment in mice with cerulein-induced AP were measured using commercial kits as described in Methods. Values are expressed as mean ± SEM. and when cerulein-induced mice were compared with control mice. and when SFN-treated AP mice were compared to cerulein-induced mice.

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