Cathepsin B Regulates Collagen Expression by Fibroblasts via Prolonging TLR2/NF-κB Activation

Figure 1

Expression of CatB and collagens III and IV by BJ fibroblasts after challenge with P.g. LPS. (a) The cell viability of BJ fibroblasts at 48 h after challenge with different dose of P.g. LPS by using cell-counting kit-8. (b) The mean mRNA expression level of CatB (3, 12, 24, and 48 h) after challenge with P.g. LPS (1 μg/mL). (c) The mean mRNA expression level of collagen III (3, 12, 24, and 48 h) after challenge with P.g. LPS (1 μg/mL). (d) The mean mRNA expression level of collagen IV (3, 12, 24, and 48 h) after challenge with P.g. LPS (1 μg/mL). Each column and bar represent the mean ± SEM ( each). The asterisks indicate a statistically significant difference from the value at the start of experiments (0 h) (, ).

(a)

(b)

(c)

(d)