Table 1: Current redox clinical investigations for the treatment of neurodegenerative diseases.

Redox therapyClinical application

Vitamin EAlzheimer’s disease [20, 21]
Parkinson’s disease [22, 23]
Multiple sclerosis [24, 25]

PolyphenolsParkinson’s disease [22, 23]
Multiple sclerosis [24, 25]
Hereditary spastic paraplegia [ClinicalTrials.gov: NCT02314208]

Coenzyme Q10Parkinson’s disease [2629]
Multiple sclerosis

MPAC
(i.e., clioquinol)
Alzheimer’s disease [3032]
Parkinson’s disease [33, 34]

-3 PUFAsMultiple sclerosis [35, 36]

MetalloporphyrinsAmyotrophic lateral sclerosis [37]

Pramipexole
(i.e., KNS-760704)
Amyotrophic lateral sclerosis [38]

MPAC: metal protein attenuating compounds; PUFAs: polyunsaturated fatty acids.