Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation

<div>Tanshinone IIA reduces intestinal neutrophil infiltration. (a) Representative images of Ly6G positive lymphocyte infiltrates in the colonic sections of DSS-treated or Tanshinone IIA + DSS-treated mice. Scale bars: 100 <svg height="9.39034pt" id="M8" style="vertical-align:-3.42943pt" version="1.1" viewbox="-0.0498162 -5.96091 7.34167 9.39034" width="7.34167pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M538 96L524 119C492 88 454 63 446 63C439 63 434 70 440 101C463 223 491 341 518 448H508L433 422L401 276C355 192 240 56 188 56C163 56 154 89 163 133C184 233 207 338 235 443L230 448L152 424L58 17C40 -60 23 -143 23 -185C23 -241 42 -261 63 -261C92 -261 117 -241 125 -227L124 -221C109 -209 89 -165 89 -103C89 -55 96 -13 105 26H107C121 -3 134 -12 151 -12C172 -12 194 -5 221 16C279 61 330 124 384 194H386C381 159 377 141 368 105C343 3 363 -12 383 -12C416 -12 486 35 538 96Z" id="g113-234"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="555" vert-adv-y="555"></glyph.data></g></svg>m. (b) Positive staining areas were quantified per high-powered microscopic field (10x) based on six sections from three independent mice from each group. Error bars indicate mean ± the SD. (c) Expression of MMP-8 in colonic tissues of DSS-treated mice measured by western blots. <i>β</i>-actin was used as a loading control. The data represent at least three experiments.</div>

Oxidative Medicine and Cellular Longevity

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Figure 3

Figure 3: Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation 

Figure 3 | Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation 