Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation

Figure 4

Inhibitory effects of Tanshinone IIA on intestinal neutrophil activation. (a) Colonic MPO activity in DSS-treated mice. (b) ROS levels in colonic tissues of DSS-treated mice. (c) The levels of inflammatory cytokines in colonic tissues. DSS remarkably increased MPO, ROS, and the four tested inflammatory cytokine levels in the colonic tissue of mice, whereas Tanshinone IIA significantly reduced their levels in mice (mean ± SD, = 5-6 mice/group).

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