Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation

Figure 6

Effect of Tanshinone IIA on neutrophil activation in vitro. (a) The LPS-stimulated neutrophils had a significant increase in MPO activities, whereas coincubation with Tanshinone IIA markedly inhibited MPO activities. (b) The LPS-stimulated neutrophils produced high levels of ROS, which was determined by flow cytometry, whereas coincubation with Tanshinone IIA markedly inhibited ROS levels. (c) The LPS-stimulated neutrophils produced higher levels of cytokines (IL-6, IL-10, and TNF-α), whereas coincubation with Tanshinone IIA markedly inhibited the production of these cytokines. Results were representative of 3 independent experiments.

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