Liver Damage in Patients with HCV/HIV Coinfection Is Linked to HIV-Related Oxidative Stress

Figure 4

Association between aggravated liver damage in HCV/HIV-coinfected individuals and higher serum GSSG concentrations. (a) Correlation between APRI (left panel) and FIB-4 (right panel) and serum GSSG concentration in HIV-positive and HIV-negative patients. Correlations of GSSG with APRI and FIB-4 were evaluated by Spearman correlation coefficient. (b) Serum GSSG concentrations in HIV-positive (right panel) and HIV-negative (left panel) patients were compared among patients with different liver ultrasound manifestations (normal, altered echostructure, and diffuse liver parenchymal lesions). The upper level (9.92 μM) of normal serum GSSG was set as the mean plus three times the standard deviation of healthy controls. Trends in GSSG levels among patients categorized by liver ultrasound manifestations were analyzed by Chi-squared tests. All values were two-tailed, with considered statistically significant.

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