Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 8194690, 11 pages
http://dx.doi.org/10.1155/2016/8194690
Research Article

Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart

1Department of Cardiac Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, China
2Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, Pharmacy School, Shihezi University, Shihezi 832002, China
3Shandong University of Traditional Chinese Medicine, Jinan 250014, China

Received 29 June 2015; Accepted 15 September 2015

Academic Editor: Catherine Brenner

Copyright © 2016 Daoxu Qu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Sekikawa, B. Y. Horiuchi, D. Edmundowicz et al., “A ‘natural experiment’ in cardiovascular epidemiology in the early 21st century,” Heart, vol. 89, no. 3, pp. 255–257, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. L. M. Buja and P. Weerasinghe, “Unresolved issues in myocardial reperfusion injury,” Cardiovascular Pathology, vol. 19, no. 1, pp. 29–35, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. Y.-M. Lee, P.-Y. Cheng, S.-Y. Chen, M.-T. Chung, and J.-R. Sheu, “Wogonin suppresses arrhythmias, inflammatory responses, and apoptosis induced by myocardial ischemia/reperfusion in rats,” Journal of Cardiovascular Pharmacology, vol. 58, no. 2, pp. 133–142, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Sanada, I. Komuro, and M. Kitakaze, “Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 301, no. 5, pp. H1723–H1741, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. K. R. Bainey and P. W. Armstrong, “Clinical perspectives on reperfusion injury in acute myocardial infarction,” American Heart Journal, vol. 167, no. 5, pp. 637–645, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. J. A. Ruiz-Ginés, S. López-Ongil, M. González-Rubio, L. González-Santiago, M. Rodríguez-Puyol, and D. Rodríguez-Puyol, “Reactive oxygen species induce proliferation of bovine aortic endothelial cells,” Journal of Cardiovascular Pharmacology, vol. 35, no. 1, pp. 109–113, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Markowski, O. Boehm, L. Goelz et al., “Pre-conditioning with synthetic CpG-oligonucleotides attenuates myocardial ischemia/reperfusion injury via IL-10 up-regulation,” Basic Research in Cardiology, vol. 108, no. 5, article 376, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. M. Tsutsumi, T. Yokoyama, Y. Horikawa, D. M. Roth, and H. H. Patel, “Reactive oxygen species trigger ischemic and pharmacological postconditioning: in vivo and in vitro characterization,” Life Sciences, vol. 81, no. 15, pp. 1223–1227, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Timmers, J. P. S. Henriques, D. P. V. de Kleijn et al., “Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury,” Journal of the American College of Cardiology, vol. 53, no. 6, pp. 501–510, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. B. Ibanez, S. Prat-González, W. S. Speidl et al., “Early metoprolol administration before coronary reperfusion results in increased myocardial salvage: analysis of ischemic myocardium at risk using cardiac magnetic resonance,” Circulation, vol. 115, no. 23, pp. 2909–2916, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. X.-N. Xu, Z.-R. Niu, S.-B. Wang et al., “Effect and mechanism of total flavonoids of bugloss on rats with myocardial ischemia and reperfusion injury,” Yao Xue Xue Bao, vol. 49, no. 6, pp. 875–881, 2014. View at Google Scholar · View at Scopus
  12. Y. Ma, Y. Wang, Y. Gao, Y. Fu, and J. Li, “Total flavonoids from Ganshanbian (Herba Hyperici Attenuati) effect the expression of CaL-α1C and KATP-Kir6.1 mRNA of the myocardial cell membrane in myocardial ischemia-reperfusion arrhythmia rats,” Journal of Traditional Chinese Medicine, vol. 34, no. 3, pp. 357–361, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Han, D. Wang, B. Yu et al., “Cardioprotection against ischemia/reperfusion by licochalcone B in isolated rat hearts,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 134862, 11 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Zhou, L. Liu, W. Wang et al., “Role of licochalcone C in cardioprotection against ischemia/reperfusion injury of isolated rat heart via antioxidant, anti-inflammatory, and anti-apoptotic activities,” Life Sciences, vol. 132, pp. 27–33, 2015. View at Publisher · View at Google Scholar
  15. M.-S. Kim and S.-H. Kim, “Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-κB in macrophages,” Archives of Pharmacal Research, vol. 34, no. 12, pp. 2101–2107, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. O. Burmistrova, J. Quintana, J. G. Díaz, and F. Estévez, “Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway,” Cancer Letters, vol. 309, no. 1, pp. 71–77, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. I.-H. Cho, J.-H. Gong, M.-K. Kang et al., “Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling,” BMC Pulmonary Medicine, vol. 14, article 122, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Ekeløf, S. E. Jensen, J. Rosenberg, and I. Gögenur, “Reduced oxidative stress in STEMI patients treated by primary percutaneous coronary intervention and with antioxidant therapy: a systematic review,” Cardiovascular Drugs and Therapy, vol. 28, no. 2, pp. 173–181, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Toth, R. Halmosi, K. Kovacs et al., “Akt activation induced by an antioxidant compound during ischemia-reperfusion,” Free Radical Biology and Medicine, vol. 35, no. 9, pp. 1051–1063, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. F.-C. Liu, H.-I. Tsai, and H.-P. Yu, “Organ-protective effects of red wine extract, resveratrol, in oxidative stress-mediated reperfusion injury,” Oxidative Medicine and Cellular Longevity, vol. 2015, Article ID 568634, 15 pages, 2015. View at Publisher · View at Google Scholar
  21. M. K. Ozer, H. Parlakpinar, Y. Cigremis, M. Ucar, N. Vardi, and A. Acet, “Ischemia-reperfusion leads to depletion of glutathione content and augmentation of malondialdehyde production in the rat heart from overproduction of oxidants: can caffeic acid phenethyl ester (CAPE) protect the heart?” Molecular and Cellular Biochemistry, vol. 273, no. 1-2, pp. 169–175, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Timmers, G. Pasterkamp, V. C. de Hoog, F. Arslan, Y. Appelman, and D. P. V. de Kleijn, “The innate immune response in reperfused myocardium,” Cardiovascular Research, vol. 94, no. 2, pp. 276–283, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. B. H. M. Heijnen, I. H. Straatsburg, N. D. Padilla, G. J. Van Mierlo, C. E. Hack, and T. M. Van Gulik, “Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model,” Clinical and Experimental Immunology, vol. 143, no. 1, pp. 15–23, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Watanabe, C. Iwahara, H. Nakayama et al., “Sevoflurane suppresses tumour necrosis factor-α-induced inflammatory responses in small airway epithelial cells after anoxia/reoxygenation,” British Journal of Anaesthesia, vol. 110, no. 4, pp. 637–645, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. F. Li, W. Wang, Y. Cao et al., “Inhibitory effects of astragalin on lipopolysaccharide-induced inflammatory response in mouse mammary epithelial cells,” Journal of Surgical Research, vol. 192, no. 2, pp. 573–581, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. N. Hu, M. Dong, and J. Ren, “Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: Role of mitochondrial injury and apoptosis,” The American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 306, no. 10, pp. R761–R771, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. Y.-B. Oh, M. Ahn, S.-M. Lee et al., “Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice,” Experimental and Molecular Medicine, vol. 45, article e23, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. L.-N. Yu, J. Yu, F.-J. Zhang et al., “Sevoflurane postconditioning reduces myocardial reperfusion injury in rat isolated hearts via activation of PI3K/Akt signaling and modulation of Bcl-2 family proteins,” Journal of Zhejiang University: Science B, vol. 11, no. 9, pp. 661–672, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. H.-F. Luan, Z.-B. Zhao, Q.-H. Zhao, P. Zhu, M.-Y. Xiu, and Y. Ji, “Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3 survival pathway,” Brazilian Journal of Medical and Biological Research, vol. 45, no. 10, pp. 898–905, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Valen, “The basic biology of apoptosis and its implications for cardiac function and viability,” Annals of Thoracic Surgery, vol. 75, no. 2, pp. S656–S660, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. Q. Chen, H. Xu, A. Xu et al., “Inhibition of Bcl-2 sensitizes mitochondrial permeability transition pore (MPTP) opening in ischemia-damaged mitochondria,” PLoS ONE, vol. 10, no. 3, Article ID e0118834, 2015. View at Publisher · View at Google Scholar
  32. C. Wang, D. A. Neff, J. G. Krolikowski et al., “The influence of B-cell lymphoma 2 protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits,” Anesthesia and Analgesia, vol. 102, no. 5, pp. 1355–1360, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Ohshima, Y. Yoshie, S. Auriol, and I. Gilibert, “Antioxidant and pro-oxidant actions of flavonoids: effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anion,” Free Radical Biology and Medicine, vol. 25, no. 9, pp. 1057–1065, 1998. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Simić, D. Manojlović, D. Šegan, and M. Todorović, “Electrochemical behavior and antioxidant and prooxidant activity of natural phenolics,” Molecules, vol. 12, no. 10, pp. 2327–2340, 2007. View at Publisher · View at Google Scholar · View at Scopus