ALT, MDA, SOD, NO, e-NOS, TNF-α, ICAM-1, HIF-1α, PI3K-Akt, and histopathology
(i) ALT, MDA, TNF-α, and ICAM-1 (ii) SOD, NO, and e-NOS (iii) HIF-1α and PI3K-Akt (iv) Lower scores of cytoplasmic vacuolization, sinusoidal congestion, and hepatocyte necrosis
Suppression of proinflammatory mediators and adhesion molecules, e-NOS mediated NO production through PI3K-Akt, and upregulation of HIF-1α through NO
(i) AST and ALT (ii) No change in Fas ligand expression (iii) Improved histology scores (iv) Preconditioning with rhEPO more effective than postconditioning in the reduction of caspase-9 activity and the increase of antiapoptotic Bcl-xL/apoptotic Bax ratio