Reduced ROS production and/or release into the cytosol via a reversible depolarization Observation: a prolonged mPTP opening triggers apoptosis and cell death [135, 136]
() Recruitment of hexokinase (HK) at the mitochondrial outer membrane [137]
Increased coupled respiration with subsequent reduced electron leak and ROS production
() Glutathionylation of the 51-kDa (NDUFV1) and 75-kDa (NDUFS1) CI subunits [79, 81, 140, 141]
Decreased activity of CI Observation: however, CI inactivation is not necessarily linked to reduced ROS production since Taylor and collaborators demonstrated that glutathionylation of CI was associated to increased superoxide production [142]