NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17β-Estradiol

Figure 1

Temporal pattern of NLRP3, ASC, caspase-1, and IL-1β gene expression after GCI and their suppression by E2 treatment. mRNA samples were collected from the hippocampus of adult female ovariectomized rats, with and without E2, at various times after GCI. (a) NLRP3, (b) ASC, (c) caspase-1, and (d) IL-1β are all expressed temporally after GCI and their expression is robustly suppressed by E2 treatment at early time points after GCI (, , GCI versus GCI + E2) ( animals per group).

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