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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 8379105, 13 pages
http://dx.doi.org/10.1155/2016/8379105
Research Article

Açai (Euterpe oleracea Mart.) Upregulates Paraoxonase 1 Gene Expression and Activity with Concomitant Reduction of Hepatic Steatosis in High-Fat Diet-Fed Rats

1Research Center in Biological Sciences, Federal University of Ouro Preto, 35400-000 Ouro Preto, MG, Brazil
2Department of Biological Sciences, Federal University of Ouro Preto, 35400-000 Ouro Preto, MG, Brazil
3Federal University of São Paulo, 04039-002 São Paulo, SP, Brazil
4Postgraduate Program in Health and Nutrition, Federal University of Ouro Preto, 35400-000 Ouro Preto, MG, Brazil
5Department of Basic Health, Federal University of Juiz de Fora, Governador Valadares Campus, 35010-177 Governador Valadares, MG, Brazil
6Department of Foods, Federal University of Ouro Preto, 35400-000 Ouro Preto, MG, Brazil

Received 25 March 2016; Revised 15 June 2016; Accepted 11 July 2016

Academic Editor: Borna Relja

Copyright © 2016 Renata Rebeca Pereira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Açai (Euterpe oleracea Mart.), a fruit from the Amazon region, has emerged as a promising source of polyphenols. Açai consumption has been increasing owing to ascribed health benefits and antioxidant properties; however, its effects on hepatic injury are limited. In this study, we evaluated the antioxidant effect of filtered açai pulp on the expression of paraoxonase (PON) isoforms and PON1 activity in rats with nonalcoholic fatty liver disease (NAFLD). The rats were fed a standard AIN-93M (control) diet or a high-fat (HF) diet containing 25% soy oil and 1% cholesterol with or without açai pulp (2 g/day) for 6 weeks. Our results show that açai pulp prevented low-density lipoprotein (LDL) oxidation, increased serum and hepatic PON1 activity, and upregulated the expression of PON1 and ApoA-I in the liver. In HF diet-fed rats, treatment with açai pulp attenuated liver damage, reducing fat infiltration and triglyceride (TG) content. In rats receiving açai, increased serum PON1 activity was correlated with a reduction in hepatic steatosis and hepatic injury. These findings suggest the use of açai as a potential therapy for liver injuries, supporting the idea that dietary antioxidants are a promising approach to enhance the defensive systems against oxidative stress.