Oxidative Medicine and Cellular Longevity / 2016 / Article / Fig 5

Review Article

Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins

Figure 5

Generation of HOCl by MPO via a chlorination cycle. In the first step, MPO is oxidized by hydrogen peroxide (H2O2) into the short-lived compound I that contains a radical cation center. Compound I is further regenerated to the educt, the ferric state MPO, either by two consecutive 1-electron steps via compound II or by oxidizing Cl to HOCl (modified in accordance with [33]).

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