Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins

Figure 5

Generation of HOCl by MPO via a chlorination cycle. In the first step, MPO is oxidized by hydrogen peroxide (H₂O₂) into the short-lived compound I that contains a radical cation center. Compound I is further regenerated to the educt, the ferric state MPO, either by two consecutive 1-electron steps via compound II or by oxidizing Cl⁻ to HOCl (modified in accordance with [33]).