Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins

Figure 9

Formation of LPLs and higher molecular weight products (particularly chlorohydrins) after incubation of different PCs with an excess of HOCl as evidenced by positive ion matrix-assisted laser desorption and ionization-time of flight mass spectrometry (MALDI-TOF MS): (a) PC 16 : 0/16 : 0; (b) PC 16 : 0/18 : 1; (c) PC 16 : 0/18 : 2; (d) PC 16 : 0/20 : 4; (e) PC 16 : 0/22 : 6. Please note that the yield of lysophosphatidylcholine (LPC, marked by the grey box) increases with the extent of unsaturation of the used PC (reprinted with slight modifications from Arnhold et al. [198] with permission from Elsevier).