An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability

Figure 2

NO production is enhanced after lipopolysaccharide incubation and inhibited by aminoguanidine (AG) treatment of organotypic cultured brain slices from the Fmr1-KO mice. NO analysis was performed in culture brain slices by a nitrate/nitrite colorimetric test kit in the culture medium. Data represent mean ± SEM. FXS versus control. FXS versus control.