Influence of Insulin Resistance and TNF-α on the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis

Table 4

Oxidative stress in patients with rheumatoid arthritis using adalimumab or etanercept.

Parameters	Etanercept	Adalimumab
CL-LOOH (cpm)	164.02 (145.51–187.05)	168.06 (162.71–197.90)	NS
AOPP (mol/L of chloramines-T equivalents)	127.44 (108.75–187.05)	167.80 (122.90–228.73)	0.071
TRAP (M Trolox/mg UA)	157.27 (15.84–183.51)	159.70 (148.83–175.58)	NS
OSI	1.10 (0.77–1.31)	0.86 (0.74–1.37)	NS

Mann-Whitney test. Data are expressed as median (25–75%). CL-LOOH, tert-butyl hydroperoxide-initiated chemiluminescence; AOPP, advanced oxidation protein product; TRAP, total radical-trapping antioxidant parameter; OSI, oxidative stress index; and NS, not significant.