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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 9057593, 10 pages
Review Article

Mitochondria in the Aging Muscles of Flies and Mice: New Perspectives for Old Characters

1Centro de Estudios Moleculares de la Célula, ICBM, Facultad de Medicina, Universidad de Chile, 8389100 Santiago, Chile
2Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, 8580000 Santiago, Chile

Received 29 January 2016; Revised 30 March 2016; Accepted 16 May 2016

Academic Editor: Felipe Dal Pizzol

Copyright © 2016 Andrea del Campo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sarcopenia is the loss of muscle mass accompanied by a decrease in muscle strength and resistance and is the main cause of disability among the elderly. Muscle loss begins long before there is any clear physical impact in the senior adult. Despite all this, the molecular mechanisms underlying muscle aging are far from being understood. Recent studies have identified that not only mitochondrial metabolic dysfunction but also mitochondrial dynamics and mitochondrial calcium uptake could be involved in the degeneration of skeletal muscle mass. Mitochondrial homeostasis influences muscle quality which, in turn, could play a triggering role in signaling of systemic aging. Thus, it has become apparent that mitochondrial status in muscle cells could be a driver of whole body physiology and organismal aging. In the present review, we discuss the existing evidence for the mitochondria related mechanisms underlying the appearance of muscle aging and sarcopenia in flies and mice.