An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation

Figure 1

CPT and NPOA cotreatment inhibits cell proliferation of two NSCLC cells. The two NSCLC cell lines, A549 and H1299, were incubated with 0.5 μM CPT and 10 μM NPOA alone or in combination, respectively. (a and b) The rates of two NSCLC cell survival lines were determined using trypan blue exclusion assay. The quantification analysis of survival cells. (c) CPT and NPOA cotreatment inhibited the colony formation of two NSCLC cells for 11 days. Afterward, the cells were fixed in 4% paraformaldehyde and Giemsa stained. (d) The quantificative analysis of the colony area. Data are presented as means ± SD (; ).

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