An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation

Figure 4

NPOA increased CPT-induced ROS production in H1299 cells. The cells indicate the concentration of CPT and NPOA alone or in combination for 6 h. (a) The levels of ROS production were determined by flow cytometer-based dihydroethidium (DHE) staining assay. (b) The quantification analysis of endogenous ROS. Data are presented as means ± SD. (c) H1299 cells were pretreated with 2 mM NAC for 3 h before CPT alone or CPT and NPOA cotreatment. (d) The quantification analysis (c). Data are presented as means ± SD (, ).

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