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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 9140925, 5 pages
Research Article

Antioxidants and Polyphenols: Concentrations and Relation to Male Infertility and Treatment Success

1Department of Obstetrics and Gynecology, Soroka Medical Center, Ben-Gurion University of the Negev, Beersheba, Israel
2Department of Public Health, Ben-Gurion University of the Negev, Beersheba, Israel
3Department of Chemical Engineering, Sami Shamoon College of Engineering, Beersheba, Israel

Received 19 February 2016; Accepted 17 April 2016

Academic Editor: Vladimir Jakovljevic

Copyright © 2016 Tali Silberstein et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oxidative stress is induced by reactive oxygen substances (ROS) that are known to affect male fertility. The aims of this study were to prospectively investigate and characterize total antioxidant and specifically polyphenols concentrations and their relations to sperm quality and fertility treatment success. During their infertility treatment, sixty-seven males were prospectively recruited to this study. After separation of the sperm from the semen sample, the semen fluid samples antioxidants and polyphenols concentrations were determined. Antioxidant concentration was significantly associated with sperm concentration and total motile count. Antioxidants concentration in the group of male with sperm concentration ≥ 15 × 106 was significantly higher than in the group of male with antioxidants concentration < 15 × 106 (830.3 ± 350 μM and 268.3 ± 220 μM, resp., ). Polyphenols concentration did not differ between the groups of sperm concentration above and below 15 × 106 (178.7 ± 121 μM and 161.7 ± 61 μM, resp., -NS). No difference was found between fertilization rates and antioxidants or polyphenols concentrations. This is the first study that reports on polyphenols concentration within semen fluid. More studies are needed in order to investigate polyphenols role in male fertility.