Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain Injury

Figure 4

Erythropoietin restores plasticity-related genes following neonatal hyperoxia. Synaptophysin (Syp), neuregulin-1 (Nrg1), and neuropilin-1 (Nrp1) mRNA expression in hemispheres of (a) P7, (b) P11, and (c) P125 rats exposed to either normoxia (21% oxygen (21%)) or hyperoxia (24 h, 80% oxygen (80%)) at P6 and treated with normal saline or 20,000 IU/kg Epo i.p. rats/group. , , and .

(a)

(b)

(c)