In Situ Evaluation of Oxidative Stress in Rat Fatty Liver Induced by a Methionine- and Choline-Deficient Diet

Table 1

Summary of the relevant observations regarding metabolic and oxidative stress alterations induced by a 1–4-week period of MCD diet, with respect to control diet.

Parameter	Diet-induced modifications
Glycogen content	Sharp decrease
Neutral lipid content	Progressive increase
Reactive Oxygen Species	Progressive increase especially surrounding lipid droplets
Peroxidated proteins	Progressive increase especially surrounding lipid droplets
Superoxide Dismutase 2 expression	Concentrated in thin rim of cytoplasm surrounding lipid droplets; trend towards decreased expression in the last 2 weeks