Therapeutic Potential of Curcumin for the Treatment of Brain Tumors

Table 1

Active clinical trials assessing therapeutic benefit of curcumin.

Trial	Status	Site	Disease	Measure	Trial ID
Vascular
Curcumin or placebo	Ongoing	Lawson Health Research Institute, CA	AAA	Serum creatinine	NCT01225094
Curcumin or placebo	Ongoing	University of Colorado Boulder, USA	Vascular aging	Arterial stiffness, arterial pulse-wave velocity, NO dilation	NCT01968564
Curcumin or placebo	Ongoing	UPEI, CA	Vascular stiffness	Arterial stiffness by tonometry, IL-6, CRP, CK	NCT02281981
Neurologic/psychiatric
Curcumin with or without yoga	Recruiting	VA Los Angeles, USA	AD	Biomarkers for MCI	NCT01811381
Curcumin	Recruiting	SHSC, CA	Adolescent bipolar disorder	Mood by CDRS-R, biomarkers	NCT01928043
Curcumin with other supplements or placebo	Ongoing	HCL, France	Fibromyalgia	QOL by GIQLI	NCT01469936
Curcumin or placebo	Ongoing	UCLA, USA	MCI, normal aging	Cognitive changes by neuropsych assessment	NCT01383161
Curcumin or placebo with omega-3 fatty acid	Invitation only	TUMS, Iran	Migraine	HA, endothelial factors, inflammation	NCT02532023
Curcumin or placebo with IFN-β1A	Ongoing	Merck Serono, Italy	Multiple sclerosis	Proportion of subjects with active T2 lesions	NCT01514370
Curcumin or placebo	Recruiting	Beersheva Mental Health Center, Israel	Schizophrenia	Psychotic symptoms (PANSS)	NCT02298985
Curcumin	Recruiting	VA Los Angeles, USA	Schizophrenia	MCCB	NCT02104752
Curcumin or placebo	Not yet recruiting	Yale, USA	Schizophrenia, schizoaffective	MCCB	NCT02476708
Gastrointestinal
Curcumin or placebo with thiopurines	Recruiting	CHU, France	Crohn’s disease	Rutgeerts endoscopic score	NCT02255370
Curcumin with triple therapy or triple therapy alone	Not yet recruiting	Rabin Medical Center, Israel	Helicobacter pylori infection	Eradication by urea breath test	NCT02018328
Curcumin with selenium and green tea or placebo	Recruiting	Meir Medical Center, Israel	Irritable bowel syndrome	QOL by questionnaires	NCT01167673
Curcumin or placebo	Not yet recruiting	NCI, USA	MAG and/or GIM	Changes in IL-1β, safety, tolerability, histologic grade	NCT02782949
Curcumin or placebo	Not yet recruiting	Schneider Children’s Medical Center, Israel	Pediatric ulcerative colitis	Disease activity by PUCAI	NCT02277223
Curcumin or placebo with 5-ASA	Recruiting	Asian Institute of Gastroenterology, India	Ulcerative colitis	Time to clinical and endoscopic remission	NCT02683733
Curcumin or placebo with 5-ASA	Recruiting	Asian Institute of Gastroenterology, India	Ulcerative colitis in remission	Percentage of patients in remission	NCT02683759
Oncologic
Curcumin or placebo	Recruiting	Emory University, USA	Breast cancer	NF-κB by ELISA	NCT01740323
Curcumin at two different doses	Recruiting	OSU, USA	Breast cancer, obesity	Adherence, tolerability, safety	NCT01975363
Curcumin or HPR Plus or placebo	Recruiting	University of Rochester, USA	Noninflammatory breast cancer	Mean radiation dermatitis severity	NCT02556632
Curcumin with standard treatment	Recruiting	UZ Leuven, Belgium	Endometrial carcinoma	Peripheral blood inflammatory markers	NCT02017353
Curcumin	Recruiting	Baylor Research Institute, USA	Squamous CIN3	Safety, feasibility, overall and pathologic response	NCT02554344
Curcumin and piperine	Recruiting	Mayo, USA	Cancer with inflamed ureteral stent	AE, max tolerable dose, optimal dose	NCT02598726
Curcumin with cholecalciferol	Recruiting	Case CCC, USA	CLL or SLL, stages 0-II	Overall response rate by NCI-WG (CLL) or Cheson (SLL)	NCT02100423
Curcumin	Recruiting	University Hospital Salzburg, Austria	Locally advanced or metastatic cancer	Safety, max tolerable dose, tumor response	NCT02138955
Curcumin or placebo	Recruiting	UPR, Puerto Rico	FAP	Tolerability and efficacy by polyp number and size	NCT00927485
Curcumin or placebo	Ongoing	NCI, USA	FAP	Laboratory biomarker analysis	NCT00641147
Curcumin with anthocyanin extract	Recruiting	The Hospital Galliera, Italy	Colorectal adenoma	β-Catenin, NFkβ, Ki-67, p53 by IHC	NCT01948661
Curcumin with 5-FU	Recruiting	Baylor Research Institute, USA	Metastatic colon cancer resistant to 5-FU	Safety, toxicity, response, biomarkers	NCT02724202
Curcumin with FOLFOX or FOLFOX alone	Ongoing	University of Leicester, UK	Metastatic colorectal cancer	Tolerable long-term dose, safety	NCT01490996
Curcumin with Avastin/FOLFIRI	Not yet recruiting	Gachon University Gil Medical Center, Korea	Metastatic colorectal cancer	PFS	NCT02439385
Curcumin with irinotecan	Recruiting	UNC Lineberger, USA	Metastatic colorectal cancer	Max tolerated dose, pharmacokinetics	NCT01859858
Curcumin or placebo with capecitabine and radiation	Ongoing	MD Anderson, USA	Rectal cancer	Pathologic complete response rate	NCT00745134
Curcumin or placebo with docetaxel	Recruiting	Centre Jean Perrin, France	Metastatic prostate cancer	Time to progression, PSA response	NCT02095717
Curcumin or placebo	Recruiting	UT Southwestern, USA	Prostate cancer	PSA, recurrence free survival	NCT02064673
Curcumin or placebo with RT	Recruiting	SBUMS, Iran	Prostate cancer	Proctitis and cystitis by CTCAE, PSA	NCT02724618
Curcumin with gemcitabine, metformin, and paclitaxel	Recruiting	City of Hope Medical Center, USA	Metastatic pancreatic cancer	Feasibility, compliance, toxicity, survival	NCT02336087
Curcumin with EGFR-TKI	Recruiting	Lady Davis Institute, CA	Nonresectable mutant EGFR NSCLC	Feasibility, adherence, AE, QOL (FACT-L), CRP	NCT02321293
Other
Curcumin or placebo	Recruiting	University of Colorado Denver, USA	ADPKD	Changes in FMD-BA and aortic pulse-wave velocity	NCT02494141
Curcumin mouthwash	Recruiting	Aurora BayCare Medical Center, USA	Chemotherapy induced mucositis	AE, toxicity, pain, healing time	NCT02300727
Curcumin or placebo	Recruiting	Lawson Health Research Institute, CA	CKD	Albuminuria, eGFR, IL-18	NCT02369549
Curcumin or placebo	Recruiting	NNFTI, Iran	DMII	Triglyceride and CRP levels	NCT02529969
Curcumin or placebo	Recruiting	NNFTI, Iran	DMII	Fasting blood sugar, antioxidant capacity	NCT02529982
Curcumin with other nutraceuticals or placebo	Not yet recruiting	IRCCS Neuromed, Italy	NAFLD	ALT, AST, GGT	NCT02369536
Curcumin in Orabase	Ongoing	SVSIDS, India	Oral submucous fibrosis	Reduction of lesion, number of bands	NCT02645656
Curcumin	Recruiting	University of Arizona, USA	Rheumatoid arthritis	AE, pharmacokinetics, ESR, CRP	NCT02543931

Source: https://www.clinicaltrials.gov/. A search performed using the keyword “curcumin” revealed 129 studies. Only active studies (48) were included in the table. Clinical trials that were complete (58), were withdrawn (8), were terminated (3), or have unknown status (12) were excluded.
CA: Canada; CCC: Comprehensive Cancer Center; CHU: Clermont-Ferrand University Hospital; HCL: Hospices Civiles de Lyon; NCI: National Cancer Institute; NNFTI: National Nutrition and Food Technology Institute; OSU: Ohio State University; SBUMS: Shahid Beheshti University of Medical Sciences; SHSC: Sunnybrook Health Sciences Centre; SVSIDS: Sri Venkata Sai Institute of Dental Sciences; TUMS: Tehran University of Medical Sciences; UCLA: University of California, Los Angeles; UK: United Kingdom; UNC: University of North Carolina; UPEI: University of Prince Edward Island; UPR: University of Puerto Rico; UT: University of Texas; USA: United States of America.5-ASA: 5-Aminosalicylic Acid; 5-FU: 5-Fluorouracil; AAA: Abdominal Aortic Aneurysm; AD: Alzheimer’s disease; ADPKD: Autosomal Dominant Polycystic Kidney Disease; AE: adverse events; ALT: Alanine Aminotransferase; AST: Aspartate Aminotransferase; CDRS-R: Children’s Depression Rating Scale-Revise; CIN: Cervical Intraepithelial Neoplasia; CK: Creatine Kinase; CKD: Chronic Kidney Disease; CLL: Chronic Lymphocytic Leukemia; CRP: C-Reactive Protein; DMII: Diabetes Mellitus Type 2; EGFR: epidermal growth factor receptor; eGFR: Estimated Glomerular Filtration Rate; ESR: Erythrocyte Sedimentation Rate; FAP: Familial Adenomatous Polyposis; FMD-BA: Brachial Artery Flow-Mediated Dilation; FOLFOX: Folinic Acid, 5-Fluorouracil, Oxaliplatin; GGT: Gamma-Glutamyl Transferase; GIM: Gastric Intestinal Metaplasia; GIQLI: Gastrointestinal Quality of Life Index; HA: headache; IHC: Immunohistochemistry; IL: Interleukin; MAG: Multifocal Atrophic Gastritis; MCCB: MATRICS Consensus Cognitive Battery; MCI: Mild Cognitive Impairment; NCI-WG: National Cancer Institute-Working Group; NAFLD: Nonalcoholic Fatty Liver Disease; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; NO: Nitric Oxide; NSCLC: Nonsmall Cell Lung Cancer; PANSS: Positive and Negative Syndrome Scale; PFS: Progression Free Survival; PSA: prostate-specific antigen; PUCAI: Pediatric Ulcerative Colitis Activity Index; QOL: quality of life; RT: Radiotherapy; SLL: Small Lymphocytic Lymphoma; TKI: Tyrosine Kinase Inhibitor; VA: Veterans Affairs.