Research Article

Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System

Figure 1

Temperature effects on the hepatic function of isolated perfused rat (IPR) livers. IPR livers were perfused in a nonrecirculating system with Krebs-Henseleit buffer at 37°C for 15 min, for stabilization, and then at the indicated temperatures for 15 min more. Results show cell viability by ALT assay in the perfusate (a) and NO production in liver homogenates (b). Values expressed as mean ± SEM of . Significant differences from livers perfused at 37°C: and .
(a)
(b)