PAN-811 Blocks Chemotherapy Drug-Induced In Vitro Neurotoxicity, While Not Affecting Suppression of Cancer Cell Growth

Figure 1

Neurotoxicity of MTX, 5-FU, or CDDP in an AO-dependent manner. (a, b) Phase contrast photographs for neurons in 25% AO and 12.5% AO, respectively (bar = 25 μm). (c) Cell membrane leakage was determined via the LDH analysis at the end of experiment for neurons in 25% AO (). (d) Cell viability was determined with MTS analysis for neurons in 12.5% AO (). The bar in green and bars in other colors indicate the cultures without an insult and with anticancer drug insults, respectively. LDH and MTS data are expressed as % of noninsulted control. Figure symbol is ,  , compared with noninsult control group by Student’s -test.

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