Research Article
PAN-811 Blocks Chemotherapy Drug-Induced In Vitro Neurotoxicity, While Not Affecting Suppression of Cancer Cell Growth
Figure 2
Dose-dependent neuroprotection of PAN-811⋅Cl⋅H2O against anticancer drug-induced neurotoxicity. (a) Phase contrast photographs for neurons in 12.5% AO (bar = 25 μm; PAN: PAN-811⋅Cl⋅H2O). (b) LDH analysis for (a) (). (c) MTS analysis for (a) (). The bar in green and bars in other colors in the graphs indicate the cultures without an insult and with anticancer drug insults, respectively. Data are expressed as % of noninsulted control. Figure symbols are , < 0.05, and , < 0.01, compared with insult group alone (without PAN-811 treatment) by one-factor ANOVA followed with Tukey HSD test.
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