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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 9573291, 13 pages
Research Article

Effects of Astragalus Polysaccharides on Dysfunction of Mitochondrial Dynamics Induced by Oxidative Stress

1School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
2Department of Gastrointestinal Surgery, Shunde First People’s Hospital, Southern Medical University, Guangdong 528300, China
3Department of Traditional Chinese Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou 510280, China
4Department of Nephrology, Southern Medical University TCM-Integrated Hospital, Guangzhou 510515, China

Received 17 August 2015; Revised 17 December 2015; Accepted 20 December 2015

Academic Editor: Ryuichi Morishita

Copyright © 2016 Yan-Feng Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper studied the chronic fatigue induced by excessive exercise and the restoration effects of Astragalus polysaccharides (APS) on mitochondria. In vivo, we found that excessive exercise could cause oxidative stress statue which led to morphological and functional changes of mitochondria. The changes, including imbalance between mitochondria fusion-fission processes, activation of mitophagy, and decrease of PGC-1α expression, could be restored by APS. We further confirmed in vitro, and what is more, we found that APS may ameliorate mitochondrial dysfunction through Sirt1 pathway. Based on the results, we may figure out part of the molecular mechanism of mitochondrial amelioration by APS.